Abstract
A concise, asymmetric synthesis of the pentacyclic framework of the cortistatins has been accomplished in 12 steps from commercially available starting materials, employing a highly diastereoselective intramolecular (4+3) cycloaddition of epoxy enolsilanes as the key step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry*
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / chemistry*
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Stereoisomerism
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Substrate Specificity
Substances
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Heterocyclic Compounds, 4 or More Rings
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Isoquinolines
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Polycyclic Compounds
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cortistatin A
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cortistatin J