The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation

Abstract

Objective: To report a case of successful paternity from a male homozygous for 5α-reductase-2 deficiency.

Design: Case report.

Setting: Academic center, division of reproductive endocrinology.

Patient(s): A 45-year-old Dominican man and his 32-year-old wife.

Intervention(s): In vitro fertilization and intracytoplasmic sperm injection.

Main outcome measure(s): Pregnancy.

Result(s): Viable twin gestation.

Conclusion(s): Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.