The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)

Jolanta Wasilewska; Edyta Sienkiewicz-Szłapka; Ewa Kuźbida; Beata Jarmołowska; Maciej Kaczmarski; Elżbieta Kostyra

doi:10.1016/j.npep.2011.01.005

The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)

Neuropeptides. 2011 Jun;45(3):189-95. doi: 10.1016/j.npep.2011.01.005. Epub 2011 Feb 21.

Authors

Jolanta Wasilewska¹, Edyta Sienkiewicz-Szłapka, Ewa Kuźbida, Beata Jarmołowska, Maciej Kaczmarski, Elżbieta Kostyra

Affiliation

¹ Department of Paediatrics, Gastroenterology and Allergic Diseases, The Medical University of Białystok, Poland.

PMID: 21334743
DOI: 10.1016/j.npep.2011.01.005

Abstract

Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apnea / blood*
Cattle
Dipeptidyl Peptidase 4 / blood*
Endorphins / blood*
Humans
Infant
Opioid Peptides / blood*
Peptide Fragments / blood*
Sudden Infant Death

Substances

Endorphins
Opioid Peptides
Peptide Fragments
beta-casomorphin 7
Dipeptidyl Peptidase 4