Abstract
Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.
Copyright © 2011 Elsevier Inc. All rights reserved.
MeSH terms
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Angiopoietin-Like Protein 4
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Angiopoietins / genetics
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Angiopoietins / metabolism*
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Animals
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Anoikis*
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Cell Line, Tumor
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Humans
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Hydrogen Peroxide / metabolism*
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Integrins / metabolism
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Mice
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Mice, Knockout
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NADPH Oxidase 1
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NADPH Oxidases / metabolism
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Protein Binding
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Signal Transduction
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Superoxides / metabolism*
Substances
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ANGPTL4 protein, human
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Angiopoietin-Like Protein 4
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Angiopoietins
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Integrins
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Superoxides
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Hydrogen Peroxide
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NADPH Oxidase 1
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NADPH Oxidases
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NOX1 protein, human