Abolition of herpes simplex cytopathic effect after treatment with peroxidase generated hypothiocyanite

J Biol Buccale. 1990 Jun;18(2):71-4.

Abstract

HSV1 suspensions were pre-incubated in a lactoperoxidase thiocyanate oxidizing system before inoculation in MRC5 fibroblast cultures. This pre-treatment could either delay or even abolish the HSV1 cytopathic potentiality. The effect was found to be time-dependent.

MeSH terms

  • Antiviral Agents
  • Cell Line
  • Fibroblasts / physiology
  • Humans
  • Lactoperoxidase / pharmacology*
  • Oxidation-Reduction
  • Simplexvirus / drug effects*
  • Simplexvirus / physiology
  • Thiocyanates / pharmacology*
  • Time Factors

Substances

  • Antiviral Agents
  • Thiocyanates
  • sodium thiocyanate
  • Lactoperoxidase
  • thiocyanate