Glucagon-like peptide-1(7-37) does not stimulate either hepatic glycogenolysis or ketogenesis

Endocrinol Jpn. 1990 Apr;37(2):293-7. doi: 10.1507/endocrj1954.37.293.

Abstract

Recent Studies have demonstrated that glucagon-like peptide-1 (GLP)(7-37) has more potent insulinotropic activity than glucagon. We therefore examined the effect of GLP-1(7-37) on liver metabolism using rat liver perfusion system. Ten nM GLP-1(7-37) did not affect glucose, ketone body and cAMP outputs from the perfused liver. Whereas, the same dose of glucagon stimulated these outputs significantly. When 10 nM GLP-1(7-37) perfused 5 min before the administration of 10 nM glucagon, the above stimulatory effects of glucagon were not affected. These results indicate that truncated GLP-1 has no effect on hepatic glycogenolysis and ketogenesis dissociating from its potent insulinotropic activity.

MeSH terms

  • Animals
  • Cyclic AMP / metabolism
  • Glucagon / pharmacology
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptides
  • Glucose / metabolism
  • Glycogen / metabolism*
  • Ketones / metabolism*
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Peptide Fragments / pharmacology*
  • Peptides / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Ketones
  • Peptide Fragments
  • Peptides
  • glucagon-like peptide 1 (7-36)
  • Glucagon-Like Peptides
  • glucagon-like peptide 1 (1-37)
  • Glucagon-Like Peptide 1
  • Glycogen
  • Glucagon
  • Cyclic AMP
  • Glucose