Abstract
Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis (aP)-inactivated poliovirus (IPV) combined vaccines are now included in various national immunization programs worldwide. We provide an overview of 16 years of clinical experience with a diphtheria (D), tetanus (T), aP, IPV and Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein (PRP∼T) combined vaccine (DTaP-IPV//PRP∼T - Pentaxim, Sanofi Pasteur, France). Good immunogenicity has been demonstrated after primary vaccination with Pentaxim, regardless of the population ethnicity and primary vaccination schedule. A booster vaccination in the second year of life also resulted in a high immune response for each antigen. Furthermore, 10 years of national surveillance in Sweden has demonstrated the effectiveness of Pentaxim in controlling pertussis. As is the case for other aP-containing combined vaccines, Pentaxim is well tolerated, with the safety profile being better than for whole-cell pertussis-containing combination vaccines for primary and booster vaccinations.
MeSH terms
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Child
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Child, Preschool
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Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage
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Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects
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Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology*
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Diphtheria-Tetanus-acellular Pertussis Vaccines / therapeutic use
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / adverse effects
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Haemophilus Vaccines / immunology*
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Haemophilus Vaccines / therapeutic use
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Humans
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Immunization Schedule
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Infant
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Infant, Newborn
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Sweden
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Tetanus Toxoid / administration & dosage
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Tetanus Toxoid / adverse effects
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Tetanus Toxoid / immunology*
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Tetanus Toxoid / therapeutic use
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Vaccination
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Vaccines, Combined / therapeutic use
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / adverse effects
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Vaccines, Conjugate / immunology*
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Vaccines, Conjugate / therapeutic use
Substances
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Haemophilus Vaccines
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Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
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Tetanus Toxoid
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Vaccines, Combined
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Vaccines, Conjugate