Abstract
This study compared immunogenicity and safety of DTaP(5)-IPV-Hib to DTaP(3)-IPV/Hib coadministered with PCV7 at 2, 3, and 4 months (primary series) and a fourth-dose booster at 12-18 months of age. Seroprotection rates for DTaP(5)-IPV-Hib were high (noninferior to DTaP(3)-IPV/Hib for the primary series) for antigens common to both vaccines and PCV7 antigens. Geometric mean concentration (GMC) for Hib antibodies were higher in the DTaP(5)-IPV-Hib group than the DTaP(3)-IPV/Hib group after the primary series and booster dose; GMCs or titers for other antigens were generally similar between groups after the primary series and booster dose. Safety profiles were similar between groups.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Clinical Trial, Phase III
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Antibodies, Bacterial / biosynthesis
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Antibodies, Bacterial / immunology
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Diphtheria-Tetanus-acellular Pertussis Vaccines* / administration & dosage
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Diphtheria-Tetanus-acellular Pertussis Vaccines* / adverse effects
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Diphtheria-Tetanus-acellular Pertussis Vaccines* / immunology
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Female
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Haemophilus Vaccines* / administration & dosage
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Haemophilus Vaccines* / adverse effects
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Haemophilus Vaccines* / immunology
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Immunization Schedule
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Infant
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Male
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Pneumococcal Vaccines* / administration & dosage
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Pneumococcal Vaccines* / adverse effects
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Pneumococcal Vaccines* / immunology
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Poliovirus Vaccines* / administration & dosage
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Poliovirus Vaccines* / adverse effects
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Poliovirus Vaccines* / immunology
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Single-Blind Method
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Vaccines, Combined* / administration & dosage
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Vaccines, Combined* / adverse effects
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Vaccines, Combined* / immunology
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / adverse effects
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Bacterial
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Haemophilus Vaccines
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines
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Poliovirus Vaccines
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Vaccines, Combined
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Vaccines, Conjugate