Abstract
Despite the prominent and worldwide use of Bacillus thuringiensis (Bt) insecticidal toxins in agriculture, knowledge of the mechanism by which they kill pests remains incomplete. Here we report genetic mapping of a membrane transporter (ABCC2) to a locus controlling Bt Cry1Ac toxin resistance in two lepidopterans, implying that this protein plays a critical role in Bt function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacillus thuringiensis Toxins
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Bacterial Proteins / toxicity*
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Bombyx / genetics
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Chromosome Mapping
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Chromosomes, Insect / genetics
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Endotoxins / toxicity*
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Evolution, Molecular
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Female
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Genetic Variation
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Hemolysin Proteins / toxicity*
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Insect Proteins / classification
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Insect Proteins / genetics
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Insecticide Resistance / genetics*
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Lepidoptera / classification
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Lepidoptera / genetics*
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Male
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Molecular Sequence Data
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Moths / genetics
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins / classification
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Multidrug Resistance-Associated Proteins / genetics
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Mutation
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Phylogeny
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Sequence Analysis, DNA
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Species Specificity
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Synteny
Substances
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Bacillus thuringiensis Toxins
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Bacterial Proteins
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Endotoxins
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Hemolysin Proteins
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Insect Proteins
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Multidrug Resistance-Associated Protein 2
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Multidrug Resistance-Associated Proteins
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insecticidal crystal protein, Bacillus Thuringiensis
Associated data
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GENBANK/JF303656
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GENBANK/JF303657
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GENBANK/JF825967
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GENBANK/JN030490
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GENBANK/JN030491
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GENBANK/JN030492
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GENBANK/JN030493
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GENBANK/JN030494
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GENBANK/JN030495
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GENBANK/JN030496
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GENBANK/JN030497
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GENBANK/JN383802
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GENBANK/JN383803
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GENBANK/JN383804
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GENBANK/JN383805
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GENBANK/JN383806
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GENBANK/JN383807
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GENBANK/JN383808
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GENBANK/JN383809
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GENBANK/JN383810
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GENBANK/JN383811
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GENBANK/JN383812
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GENBANK/JN383813
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GENBANK/JN383814