Assessing atropisomer axial chirality in drug discovery and development

J Med Chem. 2011 Oct 27;54(20):7005-22. doi: 10.1021/jm200584g. Epub 2011 Sep 15.

Authors

Steven R Laplante¹, Lee D Fader, Keith R Fandrick, Daniel R Fandrick, Oliver Hucke, Ray Kemper, Stephen P F Miller, Paul J Edwards

Affiliation

¹ Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Quebec, H7S 2G5, Canada. steven.laplante@boehringer-ingelheim.com

PMID: 21848318
DOI: 10.1021/jm200584g

No abstract available

Publication types

Review

MeSH terms

Amides / chemistry
Drug Discovery*
Heterocyclic Compounds, 4 or More Rings / chemistry
Legislation, Drug
Macrocyclic Compounds / chemistry
Models, Molecular
Pharmaceutical Preparations / chemistry*
Pharmacokinetics
Stereoisomerism
Structure-Activity Relationship
Thermodynamics
United States
United States Food and Drug Administration

Substances

Amides
Heterocyclic Compounds, 4 or More Rings
Macrocyclic Compounds
Pharmaceutical Preparations