Recent advances in the IL-17 cytokine family

Curr Opin Immunol. 2011 Oct;23(5):613-9. doi: 10.1016/j.coi.2011.07.006. Epub 2011 Aug 16.

Abstract

The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL-17A and IL-17F and their cognate receptors. To date, far less is known about the rest of the family. This review discusses recent advances in the field, with an emphasis on IL-17A biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases
  • Candida albicans / immunology
  • Candidiasis / immunology
  • Candidiasis / microbiology
  • Gene Expression Regulation / immunology*
  • Genetic Diseases, Inborn / immunology
  • Humans
  • Immunity, Innate*
  • Interleukin-17 / chemistry
  • Interleukin-17 / genetics
  • Interleukin-17 / immunology*
  • Interleukin-17 / metabolism
  • Mice
  • Protein Binding / immunology
  • Protein Structure, Tertiary
  • Receptors, Interleukin-17 / chemistry
  • Receptors, Interleukin-17 / genetics
  • Receptors, Interleukin-17 / immunology*
  • Receptors, Interleukin-17 / metabolism
  • Signal Transduction / immunology*
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism

Substances

  • IL17A protein, human
  • IL17F protein, human
  • Interleukin-17
  • Receptors, Interleukin-17