Experience-dependent expression of miR-132 regulates ocular dominance plasticity

Nat Neurosci. 2011 Sep 4;14(10):1237-9. doi: 10.1038/nn.2920.

Abstract

miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Age Factors
  • Analysis of Variance
  • Animals
  • Animals, Newborn
  • CREB-Binding Protein / genetics
  • CREB-Binding Protein / metabolism
  • Chromatin Immunoprecipitation
  • Critical Period, Psychological
  • Dominance, Ocular / drug effects
  • Dominance, Ocular / physiology*
  • Evoked Potentials, Visual / drug effects
  • Gene Expression Regulation, Developmental / physiology*
  • Green Fluorescent Proteins / genetics
  • Histones / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • MicroRNAs / chemistry
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • NIH 3T3 Cells
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Oligonucleotides / pharmacology
  • Photic Stimulation / methods
  • Protein Processing, Post-Translational / physiology
  • Sensory Deprivation
  • Visual Cortex / cytology*

Substances

  • Histones
  • MIRN132 microRNA, mouse
  • MIRN212 microRNA, mouse
  • MicroRNAs
  • Oligonucleotides
  • Green Fluorescent Proteins
  • CREB-Binding Protein