Abstract
We show here that isonitriles can perform click reactions with tetrazines in aqueous media, making them promising candidates for ligation reactions in chemical biology and polymer chemistry. This is the first time that a [4+1] cycloaddition has been used as a biocompatible ligation reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemical synthesis*
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Biocompatible Materials / chemistry
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Click Chemistry
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Cyclization
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Hydrolysis
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Molecular Structure
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Nitriles / chemistry*
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Tetrazoles / chemistry
Substances
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Biocompatible Materials
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Nitriles
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Tetrazoles