The definition of clinical pharmacology in arthritis includes different levels of measures of the clinical activity and the anatomical. The clinical measure of osteoarthritis (OA) is well validated and includes the measures of pain, disability and quality of life. Those measures should be adapted to each localisation of osteoarthritis. The measure of structural evolution of OA could be approached by the dosage in the serum of biomarkers. Several have shown some interests but none is validated in clinical practice.
© 2011 Société Française de Pharmacologie et de Thérapeutique.