Abstract
The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amines / chemistry
-
Animals
-
Cell Line
-
Dermatitis / prevention & control
-
Diamines / chemical synthesis*
-
Diamines / chemistry
-
Diamines / pharmacology
-
Disease Models, Animal
-
Humans
-
Polyamines / chemistry
-
Radiation-Protective Agents / chemical synthesis*
-
Radiation-Protective Agents / chemistry
-
Rats
-
Reactive Oxygen Species / metabolism
-
Sulfhydryl Compounds / chemical synthesis*
-
Sulfhydryl Compounds / chemistry
-
Sulfhydryl Compounds / pharmacology
Substances
-
3-(methylamino)-2-((methylamino)methyl)propane-1-thiol
-
Amines
-
Diamines
-
Polyamines
-
Radiation-Protective Agents
-
Reactive Oxygen Species
-
Sulfhydryl Compounds