Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Bioorg Med Chem. 2011 Dec 15;19(24):7720-7. doi: 10.1016/j.bmc.2011.07.053. Epub 2011 Jul 30.

Abstract

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Breast Neoplasms / drug therapy
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Female
  • Humans
  • Jurkat Cells
  • Neoplasms / drug therapy
  • Ribitol / analogs & derivatives*
  • Ribitol / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Ribitol