Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures

J Clin Pharmacol. 2012 Oct;52(10):1592-600. doi: 10.1177/0091270011422811. Epub 2011 Dec 13.

Authors

Carsten Skarke¹, Karina Kuczka, Lars Tausch, Oliver Werz, Tanja Rossmanith, Jeffrey S Barrett, Sebastian Harder, Wolfgang Holtmeier, Joachim A Schwarz

Affiliation

¹ Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. cskarke@mail.med.upenn.edu

PMID: 22167571
DOI: 10.1177/0091270011422811

No abstract available

Publication types

Clinical Trial, Phase I
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Biological Availability
Boswellia*
Cathepsin G / metabolism
Computer Simulation
Cross-Over Studies
Eicosanoids / blood
Fasting / physiology
Food-Drug Interactions*
Humans
Male
Meals
Models, Biological
Plant Extracts / administration & dosage*
Plant Extracts / blood
Plant Extracts / pharmacokinetics
Platelet Aggregation / drug effects
Triterpenes / administration & dosage
Triterpenes / blood
Triterpenes / pharmacokinetics*

Substances

11-keto-boswellic acid
Eicosanoids
Plant Extracts
Triterpenes
Cathepsin G