Therapeutic drug monitoring in the treatment of tuberculosis patients

Pulm Pharmacol Ther. 2012 Feb;25(1):83-6. doi: 10.1016/j.pupt.2011.12.001. Epub 2011 Dec 11.

Abstract

At the University Centre for Chronic Diseases Dekkerswald, a tertiary tuberculosis (TB) referral hospital in The Netherlands, therapeutic drug monitoring (TDM) is used in patients in case of relapse TB, when there is delayed response to TB treatment, and when abnormal TB drug concentrations are suspected for other reasons. In this article, a case series is presented to illustrate the value of individualized TB drug dosing in four patients with low TB drug concentrations. Increased doses of the TB drugs, especially of rifampicin, resulted in adequate peak plasma concentrations and improved clinical response to treatment in these patients, while no adverse events occurred.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Alcoholism / complications
  • Antibiotics, Antitubercular / blood
  • Antibiotics, Antitubercular / pharmacokinetics
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / pharmacokinetics
  • Antitubercular Agents / therapeutic use*
  • Chromatography, High Pressure Liquid
  • Diabetes Complications
  • Diabetes Mellitus, Type 2 / complications
  • Drug Monitoring / methods*
  • Ethambutol / blood
  • Ethambutol / pharmacokinetics
  • Humans
  • Isoniazid / blood
  • Isoniazid / pharmacokinetics
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis
  • Precision Medicine
  • Pyrazinamide / blood
  • Pyrazinamide / pharmacokinetics
  • Recurrence
  • Rifampin / blood
  • Rifampin / pharmacokinetics
  • Schizophrenia / complications
  • Sputum / microbiology
  • Treatment Failure
  • Tuberculosis / drug therapy*
  • Tuberculosis / microbiology
  • Tuberculosis, Multidrug-Resistant / drug therapy

Substances

  • Antibiotics, Antitubercular
  • Antitubercular Agents
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
  • Rifampin