Neurogenesis: premature mitotic entry lets cleavage planes take off!

Priyanka Singh; Clemens Cabernard

doi:10.1016/j.cub.2011.11.015

Neurogenesis: premature mitotic entry lets cleavage planes take off!

Curr Biol. 2012 Jan 10;22(1):R25-8. doi: 10.1016/j.cub.2011.11.015.

Authors

Priyanka Singh¹, Clemens Cabernard

Affiliation

¹ Biozentrum, University of Basel, CH-4056 Basel, Switzerland. priyanka.singh@unibas.ch

PMID: 22240477
DOI: 10.1016/j.cub.2011.11.015

Abstract

Mutations in the gene microcephalin/MCPH1 result in the neurodevelopmental disease microcephaly. A recent report provides evidence that MCPH1 controls neuroprogenitor entry into mitosis via the Chk1-Cdc25b centrosome maturation pathway.

MeSH terms

Cell Cycle Proteins
Checkpoint Kinase 1
Cytoskeletal Proteins
Humans
Microcephaly / genetics
Mitosis*
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Neurogenesis*
Protein Kinases / metabolism
cdc25 Phosphatases / metabolism

Substances

Cell Cycle Proteins
Cytoskeletal Proteins
MCPH1 protein, human
Nerve Tissue Proteins
Protein Kinases
CHEK1 protein, human
Checkpoint Kinase 1
cdc25 Phosphatases