Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma

Leuk Lymphoma. 2012 Sep;53(9):1820-3. doi: 10.3109/10428194.2012.661175. Epub 2012 Mar 1.
No abstract available

Publication types

  • Clinical Trial, Phase II
  • Letter
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Area Under Curve
  • Boronic Acids / therapeutic use
  • Bortezomib
  • Diarrhea / chemically induced
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Female
  • Histone Deacetylase Inhibitors / adverse effects
  • Histone Deacetylase Inhibitors / pharmacokinetics
  • Histone Deacetylase Inhibitors / therapeutic use*
  • Humans
  • Hydroxamic Acids / adverse effects
  • Hydroxamic Acids / pharmacokinetics
  • Hydroxamic Acids / therapeutic use*
  • Indoles / adverse effects
  • Indoles / pharmacokinetics
  • Indoles / therapeutic use*
  • Lenalidomide
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology
  • Nausea / chemically induced
  • Neutropenia / chemically induced
  • Panobinostat
  • Pyrazines / therapeutic use
  • Recurrence
  • Remission Induction
  • Thalidomide / analogs & derivatives
  • Thalidomide / therapeutic use
  • Thrombocytopenia / chemically induced
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Boronic Acids
  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • Indoles
  • Pyrazines
  • Thalidomide
  • Bortezomib
  • Panobinostat
  • Lenalidomide