Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

Jinge Zhu; Hector F DeLuca

doi:10.1016/j.abb.2012.01.013

Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

Arch Biochem Biophys. 2012 Jul 1;523(1):30-6. doi: 10.1016/j.abb.2012.01.013. Epub 2012 Jan 31.

Authors

Jinge Zhu¹, Hector F DeLuca

Affiliation

¹ Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.

PMID: 22310641
DOI: 10.1016/j.abb.2012.01.013

Abstract

Bioactivation of vitamin D(3) involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cholecalciferol / metabolism*
Cytochrome P-450 Enzyme System / chemistry
Cytochrome P-450 Enzyme System / metabolism*
Humans
Intracellular Space / enzymology
Protein Transport

Substances

Cholecalciferol
Cytochrome P-450 Enzyme System