Deciphering Alzheimer disease

Dennis Selkoe; Eckhard Mandelkow; David Holtzman

doi:10.1101/cshperspect.a011460

Deciphering Alzheimer disease

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a011460. doi: 10.1101/cshperspect.a011460.

Authors

Dennis Selkoe¹, Eckhard Mandelkow, David Holtzman

Affiliation

¹ Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. dselkoe@rics.bwh.harvard.edu

Abstract

Alzheimer disease represents an insidious impairment of intellect and emotional well-being. However, recent advances in biochemical pathology and human genetics offer promise that effective therapeutic agents may soon be developed.

Publication types

Review

MeSH terms

Alzheimer Disease / genetics*
Alzheimer Disease / therapy
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism
Biomedical Research
Humans

Substances

Amyloid beta-Peptides