Abstract
Multi drug resistant Streptococcus pneumoniae constitute a major public health concern worldwide. In this review we discuss how the transformable nature of the pneumococcus, in parallel with antimicrobial induced stress, contributes to the evolution of antimicrobial resistance; and how the introduction of the pneumococcal conjugate vaccine has affected the situation.
Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology
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Drug Resistance, Multiple, Bacterial*
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Fluoroquinolones / pharmacology*
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Humans
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Macrolides / pharmacology*
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Pneumococcal Infections / drug therapy*
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Pneumococcal Infections / prevention & control
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Pneumococcal Vaccines / therapeutic use
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Streptococcus pneumoniae / drug effects*
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Fluoroquinolones
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Macrolides
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Pneumococcal Vaccines
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beta-Lactams