Pick's disease

Adv Exp Med Biol. 2012:724:300-16. doi: 10.1007/978-1-4614-0653-2_23.

Abstract

Picks disease is a major clinicopathological disease having circumscribed atrophy in the frontotemporal lobe. Demented patients with frontotemporal atrophy are now clinically diagnosed as frontotemporal lobar degeneration (FTLD). Other underlying pathologies in patients with FTLD include FTLD with TDP-43-positive inclusions, corticobasal degeneration, progressive supranuclear palsy, basophilic inclusion body disease, neuronal intermediate filament inclusion disease and argyrophilic grain disease. In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Frontal Lobe / metabolism
  • Frontal Lobe / pathology*
  • Frontotemporal Lobar Degeneration* / classification
  • Frontotemporal Lobar Degeneration* / metabolism
  • Frontotemporal Lobar Degeneration* / pathology
  • Humans
  • Pick Disease of the Brain* / diagnosis
  • Temporal Lobe / metabolism
  • Temporal Lobe / pathology
  • tau Proteins / metabolism

Substances

  • tau Proteins