Background: Energy cost of walking (C(w)) is elevated in persons with multiple sclerosis (MS), perhaps because of gait impairment, and may impact daily activity and fatigue.
Objective: The authors examined for associations between C(w), spatiotemporal gait parameters, daily activity, and perceived fatigue in persons with mild MS.
Methods: Forty-four participants completed 4 trials of walking on a GAITRite mat and one 6-minute trial of walking on a treadmill at a constant, controlled speed of 54 m min(-1) while expired gases were analyzed for oxygen consumption. Participants also completed the Fatigue Severity Scale (FSS) and wore a waist-mounted accelerometer for 7 days.
Results: C (w) was significantly and inversely associated with gait speed (r = -.25) and stride length (r = -.32) and positively associated with double limb support (r = .27). C (w) was significantly and inversely associated with daily accelerometer activity counts (r = -.35) and positively associated with FSS scores (ρ = .31).
Conclusion: The results support the development and application of rehabilitation strategies to address impaired gait parameters as an approach to improve C(w), daily activities, and fatigue.