Factor V Leiden: how great is the risk of venous thromboembolism?

Cleve Clin J Med. 2012 Apr;79(4):265-72. doi: 10.3949/ccjm.79a.11072.

Abstract

The factor V Leiden mutation, the most common inherited cause of thrombophilia, causes a mild hypercoagulable state. We describe a 29-year-old man, heterozygous for factor V Leiden, who developed extensive pulmonary emboli with concomitant bilateral deep venous thrombosis, likely provoked by prolonged immobility during a car trip. We then review the diagnosis, therapy, screening, and prognosis of venous thromboembolism related to factor V Leiden.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anticoagulants / therapeutic use
  • Factor V / genetics*
  • Genetic Testing
  • Humans
  • Male
  • Prognosis
  • Pulmonary Embolism / complications
  • Pulmonary Embolism / diagnosis
  • Pulmonary Embolism / drug therapy
  • Thrombophilia / genetics*
  • Ultrasonography
  • Venous Thromboembolism / diagnosis
  • Venous Thromboembolism / drug therapy
  • Venous Thromboembolism / genetics*
  • Venous Thrombosis / complications
  • Venous Thrombosis / diagnostic imaging
  • Venous Thrombosis / drug therapy

Substances

  • Anticoagulants
  • factor V Leiden
  • Factor V