Abstract
It was shown on different species of laboratory animals (frogs, mice, rats) that digoxin immobilized on the copolymer was 8-15 times less toxic that its usual preparation. In this case glycoside fixed on the copolymer preserves completely its specific cardiotonic effect, i.e., possesses a wider range of the therapeutic action.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Delayed-Action Preparations
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Digoxin / administration & dosage*
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Digoxin / therapeutic use
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Digoxin / toxicity
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Drug Evaluation, Preclinical
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Electric Stimulation
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Epinephrine
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In Vitro Techniques
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Lethal Dose 50
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Male
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Mice
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Myocardial Contraction / drug effects
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Myocarditis / chemically induced
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Myocarditis / drug therapy
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Physical Exertion / drug effects
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Rana temporaria
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Rats
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Stimulation, Chemical
Substances
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Delayed-Action Preparations
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Digoxin
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Epinephrine