HOT DNAs: a novel class of developmental enhancers

Genes Dev. 2012 May 1;26(9):873-6. doi: 10.1101/gad.192583.112.

Abstract

Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Drosophila melanogaster / embryology*
  • Drosophila melanogaster / genetics*
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation, Developmental*