Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation

Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. doi: 10.1002/anie.201201358. Epub 2012 May 8.
No abstract available

Publication types

  • Research Support, American Recovery and Reinvestment Act
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Genes, ras / drug effects*
  • Molecular Structure
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology
  • Son of Sevenless Proteins / antagonists & inhibitors*

Substances

  • Small Molecule Libraries
  • Son of Sevenless Proteins