Development of catalysts for the stereoselective hydrogenation of α,β-unsaturated ketones

Frauke Maurer; Volker Huch; Angelika Ullrich; Uli Kazmaier

doi:10.1021/jo300246c

Development of catalysts for the stereoselective hydrogenation of α,β-unsaturated ketones

J Org Chem. 2012 Jun 1;77(11):5139-43. doi: 10.1021/jo300246c. Epub 2012 May 15.

Authors

Frauke Maurer¹, Volker Huch, Angelika Ullrich, Uli Kazmaier

Affiliation

¹ Institute for Organic Chemistry, Saarland University, Building C4.2, D-66123 Saarbruecken, Germany.

PMID: 22571628
DOI: 10.1021/jo300246c

Abstract

Iridium phosphinitoxazoline complexes were found to be new efficient catalysts for the asymmetric hydrogenation of arylated α,β-unsaturated ketones. Linear as well as cyclic substrates are hydrogenated with similar success, giving selectivities of up to 99.7% ee.