The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis

Bioessays. 2012 Aug;34(8):643-7. doi: 10.1002/bies.201200033. Epub 2012 May 16.

Abstract

Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blood Proteins / chemistry
  • Clathrin / chemistry*
  • Dynamins / chemistry*
  • Dynamins / classification
  • Endocytosis*
  • Evolution, Molecular*
  • Humans
  • Molecular Sequence Data
  • Neurons / chemistry
  • Organ Specificity
  • Phosphoproteins / chemistry
  • Phylogeny
  • Protein Isoforms / chemistry
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid

Substances

  • Blood Proteins
  • Clathrin
  • Phosphoproteins
  • Protein Isoforms
  • platelet protein P47
  • Dynamins