Enhancer dysfunction: how the main regulators of gene expression contribute to cancer

Siavash K Kurdistani

doi:10.1186/gb-2012-13-5-156

Enhancer dysfunction: how the main regulators of gene expression contribute to cancer

Genome Biol. 2012;13(5):156. doi: 10.1186/gb-2012-13-5-156.

Author

Siavash K Kurdistani¹

Affiliation

¹ Department of Biological Chemistry and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geff en School of Medicine, University of California, Los Angeles, CA 90095, USA. skurdistani@mednet.ucla.edu

Abstract

A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.

MeSH terms

Colonic Neoplasms / genetics
Colonic Neoplasms / metabolism
Enhancer Elements, Genetic / genetics*
Gene Expression Profiling / methods
Gene Expression*
Genome, Human
Humans
Regulatory Sequences, Nucleic Acid*
Transcription, Genetic