The role of glucocorticoids in sodium retention in cirrhotic patients: a double blind, randomized, crossover study

Scand J Gastroenterol. 2012 Sep;47(8-9):1030-6. doi: 10.3109/00365521.2012.690044. Epub 2012 Jun 7.

Abstract

Objective: Cirrhotic patients have an increased ratio of urinary cortisol to cortisone metabolites, indicating decreased renal 11-β-hydroxysteroid dehydrogenase type-2 activity. This suggests that cortisol--by activation of the mineralocorticoid receptor--may contribute to the abnormal sodium retention evident in cirrhosis. The aim was to elucidate the role of glucocorticoids in sodium retention in decompensated cirrhotic patients.

Methods: A randomized, double-blind, placebo-controlled, crossover study was performed in nine patients with alcoholic cirrhosis of the liver. A washout interval of 14 days separated the two periods. After a basal period of 36 h, dexamethasone (0.5 mg every 6 h) or placebo was given for two days. Urine was collected for 12 h periods, and the concentrations of sodium, potassium, creatinine, cortisol and cortisol metabolites were determined. Blood samples for hemoglobin, glucose, sodium, potassium, creatinine, aldosterone and cortisol were obtained daily.

Results: Dexamethasone treatment decreased S-cortisol 92.3% (82.9-93.4%) (median and range) compared with that in the basal period. Natriuresis (dexamethasone--placebo) increased 55.1 (-26.4-168.7) mmol/day (median and range). No statistically significant differences (dexamethasone--placebo) were found in changes in body weight (0.00 (-0.45-2.20) kg/day), diuresis (0.56 (-0.35-1.43) L/day) or mean arterial pressure (8.33 (-16.0-41.3) mmHg) (median and range) in reference to the preceding 24 h basal period.

Conclusion: These results indicate that endogenous glucocorticoids contribute to the sodium retention in patients with alcoholic cirrhosis of the liver.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aldosterone / blood
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Creatinine / blood
  • Creatinine / urine
  • Cross-Over Studies
  • Dexamethasone / pharmacology*
  • Dexamethasone / therapeutic use
  • Diuresis / drug effects
  • Double-Blind Method
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / metabolism*
  • Hydrocortisone / urine
  • Liver Cirrhosis, Alcoholic / complications
  • Liver Cirrhosis, Alcoholic / drug therapy
  • Liver Cirrhosis, Alcoholic / metabolism*
  • Liver Cirrhosis, Alcoholic / physiopathology
  • Male
  • Middle Aged
  • Natriuresis / drug effects*
  • Potassium / blood
  • Potassium / urine
  • Sodium / blood
  • Sodium / metabolism*
  • Sodium / urine

Substances

  • Anti-Inflammatory Agents
  • Blood Glucose
  • Hemoglobins
  • Aldosterone
  • Dexamethasone
  • Sodium
  • Creatinine
  • Potassium
  • Hydrocortisone