Lasionectrin, a naphthopyrone from a Lasionectria sp

J Nat Prod. 2012 Jun 22;75(6):1228-30. doi: 10.1021/np3002942. Epub 2012 Jun 13.

Abstract

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / blood
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Equatorial Guinea
  • Humans
  • Hypocreales / chemistry*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Naphthalenes / blood
  • Naphthalenes / chemistry
  • Naphthalenes / isolation & purification*
  • Naphthalenes / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Parasitic Sensitivity Tests
  • Plant Leaves / microbiology
  • Plasmodium falciparum / drug effects
  • Pyrones / blood
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / pharmacology

Substances

  • Antimalarials
  • Naphthalenes
  • Pyrones
  • lasionectrin