Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses

Hum Psychopharmacol. 2012 Sep;27(5):440-54. doi: 10.1002/hup.2246. Epub 2012 Jul 11.

Abstract

Objective: To compare two micronutrient (vitamins and minerals) formulas (Berocca™ and CNE™) and assess their impact on emotions and stress related to the 6.3 earthquake on February 22(nd) 2011 in Christchurch, New Zealand.

Methods: 91 adults experiencing heightened anxiety or stress 2-3 months following the earthquake were randomized to Berocca™, CNE™ low dose (CNE4), or CNE™ high dose (CNE8), for 28 days and monitored weekly via on-line questionnaires and followed 1 month post-trial. A nonrandomized control group (n = 25) completed questionnaires at baseline and 4 weeks.

Results: All treatment groups experienced significant declines in psychological symptoms (p < .001). CNE™ groups experienced greater reduction in intrusive thoughts as compared with Berocca™ (p = .05), with no group differences on other measures of psychological symptoms. However, CNE8 group reported greater improvement in mood, anxiety, and energy (p < .05) with twice as many reporting being "much" to "very much" improved and five times more likely to continue taking CNE™ post-trial than Berocca™ group. Treated participants had better outcomes on most measures over 4 weeks as compared to controls.

Conclusions: This study supports micronutrients as an inexpensive and practical treatment for acute stress following a natural disaster with a slight advantage to higher doses ACTRN 12611000460909.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Earthquakes*
  • Female
  • Fenoterol
  • Follow-Up Studies
  • Humans
  • Male
  • Micronutrients / therapeutic use*
  • Middle Aged
  • Minerals
  • New Zealand
  • Stress, Psychological / etiology
  • Stress, Psychological / therapy*
  • Treatment Outcome
  • Vitamins / therapeutic use
  • Young Adult

Substances

  • Micronutrients
  • Minerals
  • Vitamins
  • Fenoterol