Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies

Szilvia Tollas; Ilona Bereczki; Attila Sipos; Erzsébet Rőth; Gyula Batta; Lajos Daróczi; Sándor Kéki; Eszter Ostorházi; Ferenc Rozgonyi; Pál Herczegh

doi:10.1016/j.ejmech.2012.06.054

Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies

Eur J Med Chem. 2012 Aug:54:943-8. doi: 10.1016/j.ejmech.2012.06.054. Epub 2012 Jul 4.

Authors

Szilvia Tollas¹, Ilona Bereczki, Attila Sipos, Erzsébet Rőth, Gyula Batta, Lajos Daróczi, Sándor Kéki, Eszter Ostorházi, Ferenc Rozgonyi, Pál Herczegh

Affiliation

¹ Department of Pharmaceutical Chemistry, University of Debrecen, Medical and Health Science Center, Egyetem tér 1, H-4032 Debrecen, Hungary.

PMID: 22795664
DOI: 10.1016/j.ejmech.2012.06.054

Abstract

Glycopeptide antibiotic derivative teicoplanin ψ-aglycone has been bound covalently to a fullerenopyrrolidine derivative using azide-alkyne 1,3-dipolar cycloaddition reaction. The aggregation of the antibiotic-fullerene conjugate in aqueous solution has been studied. The conjugate exhibited antibacterial activity against enterococci resistant to teicoplanin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects
Chemistry Techniques, Synthetic
Fullerenes / chemistry*
Teicoplanin / analogs & derivatives*
Teicoplanin / chemistry

Substances

Anti-Bacterial Agents
Fullerenes
Teicoplanin
teicoplanin aglycone
fullerene C60