Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss

S S Jankauskas; E Y Plotnikov; M A Morosanova; I B Pevzner; L D Zorova; V P Skulachev; D B Zorov

doi:10.1134/S0006297912060144

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss

Biochemistry (Mosc). 2012 Jun;77(6):666-70. doi: 10.1134/S0006297912060144.

Authors

S S Jankauskas¹, E Y Plotnikov, M A Morosanova, I B Pevzner, L D Zorova, V P Skulachev, D B Zorov

Affiliation

¹ Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.

PMID: 22817467
DOI: 10.1134/S0006297912060144

Abstract

The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / therapeutic use*
Gentamicins / adverse effects
Hearing Loss / chemically induced
Hearing Loss / prevention & control*
Humans
Kidney / drug effects
Kidney / pathology
Male
Mitochondria / drug effects
Mitochondria / metabolism
Organ of Corti / drug effects
Organ of Corti / pathology
Oxidative Stress / drug effects
Plastoquinone / administration & dosage
Plastoquinone / analogs & derivatives*
Rats
Renal Insufficiency / chemically induced
Renal Insufficiency / mortality
Renal Insufficiency / prevention & control*
Rhodamines / administration & dosage*

Substances

10-(6'-plastoquinonyl) decylrhodamine 19
Antioxidants
Gentamicins
Rhodamines
Plastoquinone