Human metallothionein genes: structure of the functional locus at 16q13

A K West; R Stallings; C E Hildebrand; R Chiu; M Karin; R I Richards

doi:10.1016/0888-7543(90)90038-v

Human metallothionein genes: structure of the functional locus at 16q13

Genomics. 1990 Nov;8(3):513-8. doi: 10.1016/0888-7543(90)90038-v.

Authors

A K West¹, R Stallings, C E Hildebrand, R Chiu, M Karin, R I Richards

Affiliation

¹ Department of Biochemistry, University of Tasmania, Australia.

PMID: 2286373
DOI: 10.1016/0888-7543(90)90038-v

Abstract

The functional human metallothionein (MT) genes are located on chromosome 16q13. We have physically mapped the functional human MT locus by isolation and restriction digest mapping of cloned DNA. The mapped region contains all sequences on chromosome 16 that hybridize to metallothionein gene probes and comprises 14 tightly linked MT genes, 6 of which have not been previously described. This analysis defines the genetic limits of metallothionein functional diversity in the human genome.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 16*
Genes
Humans
Metallothionein / genetics*
Molecular Sequence Data
Multigene Family*
Pseudogenes

Substances

Metallothionein