Abstract
Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral activities of antiretroviral drugs against SIV. Our results emphasize the importance of the dose-response curve slope in determining the inhibitory potential of antiretroviral drugs and provide useful information for regimen selection in treating SIV-infected animals in models of therapy and virus eradication.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / blood
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Humans
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Macaca mulatta
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Simian Acquired Immunodeficiency Syndrome / drug therapy*
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / drug effects*
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Simian Immunodeficiency Virus / physiology
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Viral Envelope Proteins / genetics
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Viral Envelope Proteins