Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB

J Dermatol Sci. 2012 Oct;68(1):63-6. doi: 10.1016/j.jdermsci.2012.07.010. Epub 2012 Aug 9.

Authors

Toan The Nguyen, François Niyonsaba, Hiroko Ushio, Toshihiro Akiyama, Chanisa Kiatsurayanon, Rithee Smithrithee, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa

PMID: 22901663
DOI: 10.1016/j.jdermsci.2012.07.010

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antimicrobial Cationic Peptides / genetics
Antimicrobial Cationic Peptides / metabolism*
Cathelicidins
Cells, Cultured
Enzyme Activation
Humans
Interleukin-1 / metabolism*
Keratinocytes / drug effects
Keratinocytes / enzymology
Keratinocytes / immunology
Keratinocytes / metabolism*
Mitogen-Activated Protein Kinases / antagonists & inhibitors
Mitogen-Activated Protein Kinases / metabolism*
NF-kappa B / metabolism*
Phosphorylation
Protein Kinase Inhibitors / pharmacology
S100 Calcium Binding Protein A7
S100 Proteins / genetics
S100 Proteins / metabolism*
Signal Transduction
Time Factors
Up-Regulation

Substances

Antimicrobial Cationic Peptides
Interleukin-1
NF-kappa B
Protein Kinase Inhibitors
S100 Calcium Binding Protein A7
S100 Proteins
S100A7 protein, human
Mitogen-Activated Protein Kinases
Cathelicidins