A small molecule promotes mitochondrial fusion in mammalian cells

Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9302-5. doi: 10.1002/anie.201204589. Epub 2012 Aug 21.

Authors

Danling Wang¹, Jianing Wang, Ghislain M C Bonamy, Shelly Meeusen, Richard G Brusch, Carolina Turk, Pengyu Yang, Peter G Schultz

Affiliation

¹ Department of Chemistry, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

PMID: 22907892
DOI: 10.1002/anie.201204589

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cell Survival / drug effects
Fibroblasts / cytology
Fibroblasts / drug effects
Fibroblasts / metabolism
GTP Phosphohydrolases / deficiency
GTP Phosphohydrolases / genetics
GTP Phosphohydrolases / metabolism
Humans
Hydrazones / chemistry
Hydrazones / pharmacology*
Hydrocarbons, Chlorinated / chemistry
Hydrocarbons, Chlorinated / pharmacology*
Mice
Microscopy, Confocal
Mitochondria / metabolism*
Mitochondrial Dynamics / drug effects*
Mitochondrial Proton-Translocating ATPases / metabolism
Oxidative Phosphorylation Coupling Factors / metabolism

Substances

Hydrazones
Hydrocarbons, Chlorinated
Oxidative Phosphorylation Coupling Factors
F(6) ATPase
GTP Phosphohydrolases
Mfn2 protein, mouse
ATP5b protein, mouse
Mitochondrial Proton-Translocating ATPases