Thrombophilia and venous thromboembolism: RIETE experience

Best Pract Res Clin Haematol. 2012 Sep;25(3):285-94. doi: 10.1016/j.beha.2012.07.007. Epub 2012 Aug 17.

Abstract

RIETE is an ongoing registry of consecutive patients with acute venous thromboembolism (VTE). First we learned that in RIETE the prevalence of positive tests was 32%. One in every 2 patients younger than 50 years tested positive, with no differences between idiopathic or secondary, first event or recurrent VTE. In contrast, one in every 4 patients older than 50 years tested positive. Then, we found that the younger age of women with factor V Leiden or prothrombin G20210A may be attributed to the higher proportion of women who had the VTE during pregnancy or contraceptive use. At variance with this, 60% of men had idiopathic VTE, and only those with factor V Leiden were younger than those who tested negative. We need more patients, more data and a longer follow-up. In a near future we might be able to learn more about the outcome of VTE patients.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Age Factors
  • Contraceptives, Oral / adverse effects
  • Factor V / analysis*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Pregnancy
  • Prothrombin / analysis
  • Prothrombin / genetics
  • Registries*
  • Sex Factors
  • Thrombophilia / complications
  • Thrombophilia / diagnosis*
  • Thrombophilia / etiology
  • Venous Thromboembolism / diagnosis*
  • Venous Thromboembolism / etiology
  • Venous Thromboembolism / pathology

Substances

  • Contraceptives, Oral
  • factor V Leiden
  • Factor V
  • Prothrombin