Azo-propofols: photochromic potentiators of GABA(A) receptors

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10500-4. doi: 10.1002/anie.201205475. Epub 2012 Sep 11.

Abstract

Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Photochemical Processes
  • Propofol / analogs & derivatives*
  • Propofol / chemistry
  • Receptors, GABA-A / chemistry*

Substances

  • Azo Compounds
  • Receptors, GABA-A
  • Propofol