Insulin- and contraction-induced glucose transporter 4 traffic in muscle: insights from a novel imaging approach

Exerc Sport Sci Rev. 2013 Apr;41(2):77-86. doi: 10.1097/JES.0b013e318275574c.

Abstract

Insulin- and contraction-mediated glucose transporter 4 (GLUT4) trafficking have different kinetics in mature skeletal muscle. Intravital imaging indicates that insulin-stimulated GLUT4 trafficking differs between t-tubules and sarcolemma. In contrast, contraction-induced GLUT4 trafficking does not differ between membrane surfaces. This distinction likely is caused by differences in the underlying signaling pathways regulating GLUT4 vesicle depletion, GLUT4 membrane fusion, and GLUT4 reinternalization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diagnostic Imaging
  • Glucose Transporter Type 4 / metabolism*
  • Humans
  • Insulin / metabolism*
  • Kinetics
  • Muscle Contraction*
  • Muscle, Skeletal / metabolism*
  • Sarcolemma / metabolism

Substances

  • Glucose Transporter Type 4
  • Insulin