Abstract
A series of (2-phenyl-4H-benzopyrimodo[2,1-b][1,3]thiazol-4-yliden-4-yliden)acetonitrile derivatives have been prepared by ring transformation reaction of 4-(methylthio)-2-oxo-6-aryl-2H-pyrane-3-carbonitriles. The yield of ring transformation product is moderate to good. Furthermore the glycosidase inhibitory activities were tested by using α-amylase and α-glucosidase pancreatic, intestinal and liver enzymes, responsible for hyperglycemia in type II diabetes. The results revealed that all compounds exhibit significant glycosidase inhibitory activity.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetonitriles / chemical synthesis
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Acetonitriles / chemistry*
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Acetonitriles / metabolism
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Acetonitriles / pharmacology*
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Amylases / antagonists & inhibitors
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Amylases / metabolism
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Animals
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Enzyme Activation / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Glycoside Hydrolase Inhibitors*
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / metabolism
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Intestines / enzymology
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Liver / enzymology
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Mice
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Pancreas / enzymology
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Protein Binding
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Swine
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alpha-Glucosidases / metabolism
Substances
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Acetonitriles
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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Amylases
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alpha-Glucosidases
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acetonitrile