Metabolomics platforms for genome wide association studies--linking the genome to the metabolome

Jerzy Adamski; Karsten Suhre

doi:10.1016/j.copbio.2012.10.003

Metabolomics platforms for genome wide association studies--linking the genome to the metabolome

Curr Opin Biotechnol. 2013 Feb;24(1):39-47. doi: 10.1016/j.copbio.2012.10.003. Epub 2012 Oct 25.

Authors

Jerzy Adamski¹, Karsten Suhre

Affiliation

¹ Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany. adamski@helmholtz-muenchen.de

PMID: 23102864
DOI: 10.1016/j.copbio.2012.10.003

Abstract

Genome-wide association studies (GWAS) reveal links between genetic variance and predisposition to disease. With the advent of modern 'omics-technologies', GWAS can now identify the genetic factors that influence intermediate traits on pathways to disease, such as blood concentrations of carbohydrates, lipids, amino acids, and secondary metabolites, hormones and signal molecules. At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cohort Studies
Environment
Genome / genetics*
Genome-Wide Association Study / methods*
Humans
Metabolic Networks and Pathways / genetics
Metabolome / genetics*
Metabolomics / methods*
Phenotype