The power of yeast to model diseases of the powerhouse of the cell

Front Biosci (Landmark Ed). 2013 Jan 1;18(1):241-78. doi: 10.2741/4098.

Abstract

Mitochondria participate in a variety of cellular functions. As such, mitochondrial diseases exhibit numerous clinical phenotypes. Because mitochondrial functions are highly conserved between humans and Saccharomyces cerevisiae, yeast are an excellent model to study mitochondrial disease, providing insight into both physiological and pathophysiological processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism
  • Cardiolipins / biosynthesis
  • Carrier Proteins / genetics
  • DNA Replication
  • DNA, Mitochondrial / biosynthesis
  • DNA, Mitochondrial / genetics
  • Electron Transport Complex II / genetics
  • Electron Transport Complex III / genetics
  • Electron Transport Complex IV / genetics
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Metalloendopeptidases / metabolism
  • Mitochondria / genetics
  • Mitochondria / physiology*
  • Mitochondrial ADP, ATP Translocases / genetics
  • Mitochondrial Diseases / genetics*
  • Mitochondrial Membrane Transport Proteins / metabolism
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Mitochondrial Proteins / metabolism
  • Mitochondrial Proton-Translocating ATPases
  • Models, Biological*
  • Mutation
  • Oxidative Phosphorylation
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Succinate Dehydrogenase / genetics

Substances

  • Cardiolipins
  • Carrier Proteins
  • DNA, Mitochondrial
  • Membrane Proteins
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Mitochondrial Proteins
  • SYM1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • TOM7 protein, S cerevisiae
  • Mitochondrial ADP, ATP Translocases
  • Electron Transport Complex II
  • Succinate Dehydrogenase
  • Electron Transport Complex IV
  • Metalloendopeptidases
  • Adenosine Triphosphatases
  • YTA12 protein, S cerevisiae
  • Mitochondrial Proton-Translocating ATPases
  • Electron Transport Complex III
  • oligomycin sensitivity-conferring protein