Significance of the identification in the Horn of Africa of an exceptionally deep branching Mycobacterium tuberculosis clade

PLoS One. 2012;7(12):e52841. doi: 10.1371/journal.pone.0052841. Epub 2012 Dec 27.

Abstract

Molecular and phylogeographic studies have led to the definition within the Mycobacterium tuberculosis complex (MTBC) of a number of geotypes and ecotypes showing a preferential geographic location or host preference. The MTBC is thought to have emerged in Africa, most likely the Horn of Africa, and to have spread worldwide with human migrations. Under this assumption, there is a possibility that unknown deep branching lineages are present in this region. We genotyped by spoligotyping and multiple locus variable number of tandem repeats (VNTR) analysis (MLVA) 435 MTBC isolates recovered from patients. Four hundred and eleven isolates were collected in the Republic of Djibouti over a 12 year period, with the other 24 isolates originating from neighbouring countries. All major M. tuberculosis lineages were identified, with only two M. africanum and one M. bovis isolates. Upon comparison with typing data of worldwide origin we observed that several isolates showed clustering characteristics compatible with new deep branching. Whole genome sequencing (WGS) of seven isolates and comparison with available WGS data from 38 genomes distributed in the different lineages confirms the identification of ancestral nodes for several clades and most importantly of one new lineage, here referred to as lineage 7. Investigation of specific deletions confirms the novelty of this lineage, and analysis of its precise phylogenetic position indicates that the other three superlineages constituting the MTBC emerged independently but within a relatively short timeframe from the Horn of Africa. The availability of such strains compared to the predominant lineages and sharing very ancient ancestry will open new avenues for identifying some of the genetic factors responsible for the success of the modern lineages. Additional deep branching lineages may be readily and efficiently identified by large-scale MLVA screening of isolates from sub-Saharan African countries followed by WGS analysis of a few selected isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cluster Analysis
  • Djibouti
  • Genes, Bacterial
  • Genotype
  • Humans
  • Kenya
  • Minisatellite Repeats
  • Models, Genetic
  • Multilocus Sequence Typing
  • Mutation
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Phylogeny
  • Phylogeography
  • Polymorphism, Single Nucleotide
  • Somalia
  • Sudan
  • Tuberculosis / microbiology*

Grants and funding

The study was funded by CNRS, Paris-Sud University, the french military health services, and the french Direction Générale de l'Armement (DGA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.