Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation

Nutrients. 2013 Jan 10;5(1):111-48. doi: 10.3390/nu5010111.

Abstract

Vitamin D, the sunshine vitamin, has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, cardiovascular disease and infectious diseases. Vitamin D deficiency is now recognized as a global pandemic. The major cause for vitamin D deficiency is the lack of appreciation that sun exposure has been and continues to be the major source of vitamin D for children and adults of all ages. Vitamin D plays a crucial role in the development and maintenance of a healthy skeleton throughout life. There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin D should be supplemented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Cardiovascular Diseases / physiopathology
  • Child
  • Dietary Supplements
  • Female
  • Fractures, Bone / physiopathology
  • Humans
  • Male
  • Muscle, Skeletal / physiopathology
  • Neoplasms / physiopathology
  • Osteoporosis / physiopathology
  • Skin Physiological Phenomena*
  • Sunlight*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / pharmacology
  • Vitamin D / physiology
  • Vitamin D Deficiency / physiopathology
  • Vitamin D Deficiency / prevention & control
  • Vitamin D Deficiency / therapy*

Substances

  • Vitamin D
  • 25-hydroxyvitamin D