It is well-known that the general health information seeking lay-person, regardless of his/her education, cultural background, and economic status, is not as familiar with-or comfortable using-the technical terms commonly used by healthcare professionals. One of the primary reasons for this is due to the differences in perspectives and understanding of the vocabulary used by patients and providers even when referring to the same health concept. To bridge this "knowledge gap," consumer health vocabularies are presented as a solution. In this study, we introduce the Mayo Consumer Health Vocabulary (MCV)-a taxonomy of approximately 5,000 consumer health terms and concepts-and develop text-mining techniques to expand its coverage by integrating disease concepts (from UMLS) as well as non-genetic (from deCODEme) and genetic (from GeneWiki+ and PharmGKB) risk factors to diseases. These steps led to adding at least one synonym for 97% of MCV concepts with an average of 43 consumer friendly terms per concept. We were also able to associate risk factors to 38 common diseases, as well as establish 5,361 Disease:Gene pairings. The expanded MCV provides a robust resource for facilitating online health information searching and retrieval as well as building consumer-oriented healthcare applications.